The new version of DE-kupl now includes a higly sensitive differential procedure based of DESeq2.
The bioRxiv preprint has also been udated with a detailed description of this new procedure as well as a cross-validationg test of DE-kupl using idenpendant datasets from GTEx and HPA (Human Protein Atlas) RNA-Seq data.
The first version of DE-kupl publication has been released as a pre-print on bioRxiv.
Some reactions about the article on twitter.
This is quite nice. There have been similar ideas bubbling a few places, but these approaches so smart https://t.co/aqV7WgIPvF— Craig Kaplan (@TriggerLoop) 5 avril 2017
Exploratory RNAseq done right! Exhaustive capture of biological variation in RNAseq data through k-mer decomposition https://t.co/da67Pa7uN4— Martin A. Smith (@martinalexsmith) 5 avril 2017
RNAseq friends should check this out. Super interesting idea. Excited to kick the tires. https://t.co/fJBKehApk5— Matt MacManes (@macmanes) 3 avril 2017
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Jérôme Audoux, Nicolas Philippe, Rayan Chikhi, Mikaël Salson, Marc Gabriel, Thérèse Commes, Daniel Gautheret. Exhaustive capture of biological variation in RNA-seq data through k-mer decomposition doi: https://doi.org/10.1101/122937